A molecular arms race between host innate antiviral response and emerging human coronaviruses.
Identifieur interne : 001090 ( Main/Exploration ); précédent : 001089; suivant : 001091A molecular arms race between host innate antiviral response and emerging human coronaviruses.
Auteurs : Lok-Yin Roy Wong [République populaire de Chine] ; Pak-Yin Lui [République populaire de Chine] ; Dong-Yan Jin [République populaire de Chine]Source :
- Virologica Sinica [ 1995-820X ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (pharmacologie), Coronavirus (), Coronavirus (immunologie), Coronavirus (physiologie), Humains, Immunité innée (), Immunité innée (immunologie), Infections à coronavirus (immunologie), Infections à coronavirus (métabolisme), Infections à coronavirus (virologie), Interactions hôte-pathogène.
- MESH :
- immunologie : Coronavirus, Immunité innée, Infections à coronavirus.
- métabolisme : Infections à coronavirus.
- pharmacologie : Antiviraux.
- physiologie : Coronavirus.
- virologie : Infections à coronavirus.
- Animaux, Coronavirus, Humains, Immunité innée, Interactions hôte-pathogène.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (pharmacology), Coronavirus (drug effects), Coronavirus (immunology), Coronavirus (physiology), Coronavirus Infections (immunology), Coronavirus Infections (metabolism), Coronavirus Infections (virology), Host-Pathogen Interactions, Humans, Immunity, Innate (drug effects), Immunity, Innate (immunology).
- MESH :
- chemical , pharmacology : Antiviral Agents.
- drug effects : Coronavirus, Immunity, Innate.
- immunology : Coronavirus, Coronavirus Infections, Immunity, Innate.
- metabolism : Coronavirus Infections.
- physiology : Coronavirus.
- virology : Coronavirus Infections.
- Animals, Host-Pathogen Interactions, Humans.
Abstract
Coronaviruses have been closely related with mankind for thousands of years. Community-acquired human coronaviruses have long been recognized to cause common cold. However, zoonotic coronaviruses are now becoming more a global concern with the discovery of highly pathogenic severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronaviruses causing severe respiratory diseases. Infections by these emerging human coronaviruses are characterized by less robust interferon production. Treatment of patients with recombinant interferon regimen promises beneficial outcomes, suggesting that compromised interferon expression might contribute at least partially to the severity of disease. The mechanisms by which coronaviruses evade host innate antiviral response are under intense investigations. This review focuses on the fierce arms race between host innate antiviral immunity and emerging human coronaviruses. Particularly, the host pathogen recognition receptors and the signal transduction pathways to mount an effective antiviral response against SARS and MERS coronavirus infection are discussed. On the other hand, the counter-measures evolved by SARS and MERS coronaviruses to circumvent host defense are also dissected. With a better understanding of the dynamic interaction between host and coronaviruses, it is hoped that insights on the pathogenesis of newly-identified highly pathogenic human coronaviruses and new strategies in antiviral development can be derived.
DOI: 10.1007/s12250-015-3683-3
PubMed: 26786772
Affiliations:
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last="Jin">Dong-Yan Jin</name><affiliation wicri:level="1"><nlm:affiliation>School of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, China. dyjin@hku.hk.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author></analytic><series><title level="j">Virologica Sinica</title><idno type="eISSN">1995-820X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Coronavirus (drug effects)</term><term>Coronavirus (immunology)</term><term>Coronavirus (physiology)</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (metabolism)</term><term>Coronavirus 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Community-acquired human coronaviruses have long been recognized to cause common cold. However, zoonotic coronaviruses are now becoming more a global concern with the discovery of highly pathogenic severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronaviruses causing severe respiratory diseases. Infections by these emerging human coronaviruses are characterized by less robust interferon production. Treatment of patients with recombinant interferon regimen promises beneficial outcomes, suggesting that compromised interferon expression might contribute at least partially to the severity of disease. The mechanisms by which coronaviruses evade host innate antiviral response are under intense investigations. This review focuses on the fierce arms race between host innate antiviral immunity and emerging human coronaviruses. Particularly, the host pathogen recognition receptors and the signal transduction pathways to mount an effective antiviral response against SARS and MERS coronavirus infection are discussed. On the other hand, the counter-measures evolved by SARS and MERS coronaviruses to circumvent host defense are also dissected. With a better understanding of the dynamic interaction between host and coronaviruses, it is hoped that insights on the pathogenesis of newly-identified highly pathogenic human coronaviruses and new strategies in antiviral development can be derived.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wong, Lok Yin Roy" sort="Wong, Lok Yin Roy" uniqKey="Wong L" first="Lok-Yin Roy" last="Wong">Lok-Yin Roy Wong</name></noRegion><name sortKey="Jin, Dong Yan" sort="Jin, Dong Yan" uniqKey="Jin D" first="Dong-Yan" last="Jin">Dong-Yan Jin</name><name sortKey="Lui, Pak Yin" sort="Lui, Pak Yin" uniqKey="Lui P" first="Pak-Yin" last="Lui">Pak-Yin Lui</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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